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Tuesday, July 16, 2019

6:38:00 AM CEST

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Quotes... Extracted quotes

Eric Strauss said: "We used a combination of gene therapy and chemotherapy to combat prostate cancer in mice," "We chose the weapon we considered most likely to work as a tumor suppressant," External link

eurekalert Wednesday, June 26, 2019 9:23:00 PM CEST

Eric Strauss said: "First, we implanted human prostate cancer cells in the mice and waited for tumors to grow. We then injected the virus directly into the tumors. We repeated this procedure several times. On two of these occasions, we also systemically administered cabazitaxel, a drug commonly used in chemotherapy. After that, we observed the mice to see if the tumors developed," External link

eurekalert Wednesday, June 26, 2019 9:23:00 PM CEST

Eric Strauss said: "Individual treatments with p53 or cabazitaxel alone had an intermediate effect in terms of controlling tumor growth, but the combination had the most striking result, totally inhibiting tumors," External link

eurekalert Wednesday, June 26, 2019 9:23:00 PM CEST

Eric Strauss said: "In our study, we used a subtherapeutic dose, which was not sufficient to control the tumor. This was done to avoid leukopenia," External link

eurekalert Wednesday, June 26, 2019 9:23:00 PM CEST

Eric Strauss said: "Both p53 and interferon-beta can kill tumor cells. We wanted to combine them for cell death to wake up the immune system. This is known as immunogenic cell death," External link

eurekalert Wednesday, June 26, 2019 9:23:00 PM CEST

Eric Strauss said: "When this happens, the immune system combats tumor cells both at the treatment site and in tumors located elsewhere," "Our goal now is to refine these approaches. We're engaged in experiments to find out whether they deserve to advance to the stage of clinical trials in human patients" External link

eurekalert Wednesday, June 26, 2019 9:23:00 PM CEST

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