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Pedro Simas explains: "Our research group studies the functions of this viral protein LANA for many years. Now, we have discovered a region of LANA that is key for virus to persist. Of particular interest, this LANA region preferentially interacts with a form of a well-known tumor suppressor protein called p53. The interesting aspect of this discovery is that this region, an acidic domain reader, discerns the presence of a specific post-translation modification, acetylation, an add-on attribute that proteins might acquire while they are being produced by the cell" External link

medindia Tuesday, August 18, 2020 7:18:00 AM CEST

Pedro Simas explains: "Our research group studies the functions of this viral protein LANA for many years. Now, we have discovered a region of LANA that is key for virus to persist. Of particular interest, this LANA region preferentially interacts with a form of a well-known tumor suppressor protein called p53. The interesting aspect of this discovery is that this region, an acidic domain reader, discerns the presence of a specific post-translation modification, acetylation, an add-on attribute that proteins might acquire while they are being produced by the cell" External link

eurekalert Monday, August 17, 2020 9:29:00 PM CEST

Charlie Wood said: “It was a turning point of the AIDS epidemic,” External link

technology Tuesday, August 11, 2020 7:59:00 PM CEST

John West said: “We have built from absolutely zero two labs in two countries in major hospitals on par with any facility on the continent,” “Every year we try to incrementally add instrumentation, but it won’t work if it rusts. We need personnel and to keep it in country. At last count we have trained more than 60 trainees, and all but two or three are still somewhere in the program, as professors, as clinicians and in the government” External link

technology Tuesday, August 11, 2020 7:59:00 PM CEST

Charlie Wood said: “We’re on second and third generation of trainees in Zambia,” “This is the way we do hybrid programs to train people and treat human resources as infrastructure. The key is to empower them. Key to that progress was helping to change the mentality of the hospitals by getting doctors on board as researchers. Once they could see the benefit of research on their patients, they wanted to help” External link

technology Tuesday, August 11, 2020 7:59:00 PM CEST

Charlie Wood said: “They have the training and the facility to do their work,” “That’s the key to building transparency and relationships. Just having it run by U.S. people is not the right model. They want a bigger role to be played by locals. Chipepo and I are co-investigators. I don’t think it’s fair to go there, take all the samples, and then leave. That’s not the way to sustain a relationship” External link

technology Tuesday, August 11, 2020 7:59:00 PM CEST

John West said: “We have built from absolutely zero two labs in two countries in major hospitals on par with any facility on the continent,” “Every year we try to incrementally add instrumentation, but it won’t work if it rusts. We need personnel and to keep it in country. At last count we have trained more than 60 trainees, and all but two or three are still somewhere in the program, as professors, as clinicians and in the government” External link

technology Tuesday, August 11, 2020 10:18:00 AM CEST

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