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Monday, November 18, 2019

2:46:00 PM CET

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Leonardo Ferreira said: “Most T cells are dedicated to defending our body from pathogenic invaders and cancer. They recognize peptides derived from viruses, bacteria, or proteins mutated in cancer and target the cells presenting those peptides for destruction. T regs are dedicated to suppressing immune responses and maintaining homeostasis of the immune system; they are not dedicated to searching and destroying,” External link

the-scientist Monday, October 21, 2019 8:01:00 PM CEST

Leonardo Ferreira said: “CRISPR allows one to integrate the CAR gene in the native T cell receptor (TCR) locus. This means that, unlike lentiviral and retroviral transduction, which introduces multiple copies of the CAR gene per cell at random places in the genome driven by a non-physiological promoter, a CAR knocked in the TCR locus is under the native gene regulation of the TCR and is present at a controlled copy number. This makes a big difference in terms of the uniformity of CAR expression, T cell expansion, and function,” External link

the-scientist Monday, October 21, 2019 8:01:00 PM CEST

Leonardo Ferreira said: “Single cell analyses are key to developing and validating any kind of cell therapy,” “For CAR T regs in particular, it is key to perform single cell techniques to accurately trace T reg stability, cytokine production, and receptor expression, as T regs are known to be heterogeneous” External link

the-scientist Monday, October 21, 2019 8:01:00 PM CEST

Leonardo Ferreira said: “T regs secrete tissue repair molecules,” “There are currently clinical trials using T regs against amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurons. In the future, I predict we will be able to use CAR-T regs not only to suppress autoimmunity and prevent organ rejection, but also to treat inflammation and aid with wound healing and regeneration” External link

the-scientist Monday, October 21, 2019 8:01:00 PM CEST

Leonardo Ferreira said: “As an immunologist, I tend to favor protein over RNA,” External link

the-scientist Monday, October 21, 2019 8:01:00 PM CEST

David Nichols says: “If you had the equipment, it probably still isn’t quite as straightforward as synthesis and wouldn’t be as clean,” “The final product would probably require more purification than synthetic material, the way they’ve got it worked out” External link

inverse Thursday, October 3, 2019 2:17:00 PM CEST

David Nichols says: “I didn’t think it would happen in my lifetime, frankly,” “I hope I can live another five years and actually see it get approved and actually start getting out there as an approved medicine” External link

inverse Thursday, October 3, 2019 2:17:00 PM CEST

Andrew Jones explained: “We are taking the DNA from the mushroom that encodes its ability to make this product and putting it in E. coli ,” “It’s similar to the way you make beer, through a fermentation process” External link

geek Tuesday, October 1, 2019 3:59:00 PM CEST

Harris Wang says: “We thought we could exploit this idea for synthetic biology,” External link

newsmedical Wednesday, August 21, 2019 5:32:00 PM CEST

Darren Seifer says: “Plant-based burgers allow consumers to substitute without sacrifice. They get the ‘burger’ experience while assuaging their need for more protein and social concerns,” External link

marketwatch Tuesday, August 6, 2019 9:00:00 PM CEST

Sonia Trigueros says: “We cannot say ‘oh, we’re totally safe’ we need to work on that: we need to do better protocols to see toxicity,” External link

scidev Thursday, August 1, 2019 2:07:00 PM CEST

Sonia Trigueros says: “I’m confident that we are on the right path, but we still have a lot work to do,” “It’s a very young technology, so we need to have a positive view” External link

scidev Thursday, August 1, 2019 2:07:00 PM CEST

Darren Seifer says: “Plant-based burgers allow consumers to substitute without sacrifice. They get the ‘burger’ experience while assuaging their need for more protein and social concerns,” External link

marketwatch Friday, July 19, 2019 11:45:00 AM CEST

Darren Seifer says: “Plant-based burgers allow consumers to substitute without sacrifice. They get the ‘burger’ experience while assuaging their need for more protein and social concerns,” External link

marketwatch Wednesday, July 17, 2019 9:39:00 PM CEST

Michael Timko said: “The art of the research has been creating the extraction technique,” External link

thechemicalengineer Tuesday, May 21, 2019 7:38:00 PM CEST

Michael Timko said: “We used 30 years' worth of scientific experience to build this process,” “Just having an organism that can grow in supercritical carbon dioxide isn’t much of a splash but producing isobutanol and being able to siphon it off at the right rate — all together that’s a big, big splash” External link

thechemicalengineer Tuesday, May 21, 2019 7:38:00 PM CEST

Michael Timko said: “Think of Bacillus megaterium as a little chemical factory,” External link

thechemicalengineer Tuesday, May 21, 2019 7:38:00 PM CEST

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