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Monday, May 28, 2018

3:31:00 AM CEST

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Nobuyuki Takakura explained: "Vascular normalization by angiogenesis inhibitors, such as vascular endothelial growth factor (VEGF) signaling inhibitors, is a promising method for improvement of chemotherapy. However, it is unclear how we can recognize the 'window of opportunity' for the tumor vascular normalizing period for effective timing of anticancer drug treatment. Therefore, biomarkers delineating this window are essential," External link

rdmag Monday, April 9, 2018 4:30:00 PM CEST

Nobuyuki Takakura commented: "Our data showed that PSF1-promotor-EGFP mice may be utilized to visualize proliferating ECs by their EGFP expression," "Experimentation on non-proliferative ECs revealed that these quiet cells strongly expressed VEGFR1 and a cell surface protein CD109. CD109 expression in ECs increased three to five days after injection of bevacizumab into human colorectal adenocarcinoma HT29-bearing mice, coinciding with normalization of tumor vessels. Though on day 5 after bevacizumab injection, functional vessels increased and hypoxic regions significantly decreased, by day 8, hypoxic regions increased again" External link

rdmag Monday, April 9, 2018 4:30:00 PM CEST

Nobuyuki Takakura remarked: "Since CD109 is highly expressed in dormant ECs, we suggest it can be used to detect normalized blood vessels, thus allowing identification of the 'window of opportunity' for optimal delivery of chemotherapeutics," External link

rdmag Monday, April 9, 2018 4:30:00 PM CEST

James Sheen commented: "We're very pleased that Yaya would join our team to launch and lead our e-commerce business. She has impressive experience in the e-commerce business and various businesses related to rural China, which fits very well into our strategy of developing a Blockchain technology based rural e-commerce platform," External link

marketwatch Monday, March 26, 2018 9:01:00 PM CEST

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