Latest News About - Chagas disease

 
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Monday, August 20, 2018

4:22:00 PM CEST

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Luis Roberto said: “Given the social and economic conditions that Paraguay has faced throughout the years, the fact that the country has been able to eliminate one of the primary sources of infection, is a great example for other countries also fighting against this disease,” External link

outbreaknewstoday Wednesday, August 15, 2018 11:56:00 AM CEST

Luis Roberto said: “Paraguay has a history of sustained efforts over a period of decades, which has led to very important results,” External link

outbreaknewstoday Wednesday, August 15, 2018 11:56:00 AM CEST

Rafael Guido said: "In mice, the number of parasites in the bloodstream (parasitemia) had fallen 62% by the fifth day of the test. After 30 days, all the mice given doses of the molecule were still alive," External link

medindia Monday, August 13, 2018 7:10:00 AM CEST

Rafael Guido said: "During the synthesis procedure, we realized the huge pharmacological potential of these molecules," "We then made new structural modifications to the pyrroloquinoline portion using efficient catalytic processes, and from the structure obtained, we created a new molecule with hundreds of times more firepower against P. falciparum and no increase in toxicity" External link

medindia Monday, August 13, 2018 7:10:00 AM CEST

Rafael Guido said: "This strategy for obtaining energy without toxicity is like sweeping dust under the carpet. The heme group stays there, but in a polymerized insoluble form that isn't toxic to the parasite," External link

medindia Monday, August 13, 2018 7:10:00 AM CEST

Rafael Guido said: "If the number of deaths is so high while we have an effective drug, it will be even higher in future if we don't develop new drugs," "Malaria is the world's deadliest parasitic disease, even with the relatively effective treatment we currently have" External link

medindia Monday, August 13, 2018 7:10:00 AM CEST

Rafael Guido said: "If the pharmokinetic properties, especially solubility, absorption, distribution, metabolism and excretion, aren't adequate, the compound can build up in the organism and become toxic to the patient, making it inappropriate for treatment. After completing this step, we plan to perform preclinical and clinical trials," External link

medindia Monday, August 13, 2018 7:10:00 AM CEST

Rafael Guido declaró: "En las pruebas realizadas al quinto día de estudio, la molécula logró disminuir en un 62% de la cantidad de parásitos presentes en la sangre (parasitemia). Al cabo de los 30 días de pruebas, todos los ratones que ingirieron doses de la molécula sobrevivieron" External link

noticiasdelaciencia Saturday, August 11, 2018 8:25:00 AM CEST

Rafael Guido dijo: "Durante el trabajo de síntesis nos dimos cuenta del enorme potencial farmacológico de esas moléculas. Entonces efectuamos nuevas modificaciones estructurales en la parte de pirroloquinolina, empleando eficientes procesos catalíticos, y a partir de la estructura obtenida creamos una nueva molécula con una potencia ampliada centenas de veces contra el P. falciparum, y sin aumentar su toxicidad" External link

noticiasdelaciencia Saturday, August 11, 2018 8:25:00 AM CEST

Rafael Guido dijo: "Si las propiedades del compuesto, tales como solubilidad, absorción, distribución, metabolismo y excreción no fueran adecuadas, éste podría acumularse en el organismo y así volverse tóxico para el paciente, lo que inviabilizaría el medicamento. Una vez que concluyamos esta etapa, nuestro objetivo consistirá en realizar las pruebas preclínicas y los ensayos clínicos" External link

noticiasdelaciencia Saturday, August 11, 2018 8:25:00 AM CEST

Rafael Guido dijo: "Esta estrategia del parásito consistente en obtener energía sin intoxicarse funciona más o menos como barrer el polvo debajo de la alfombra. El grupo hemo sigue estando presente, pero en un forma polimerizada e insoluble que no es tóxica para el parásito" External link

noticiasdelaciencia Saturday, August 11, 2018 8:25:00 AM CEST

Rafael Guido dijo: "Si hoy en día, con un medicamento eficaz, tenemos una cantidad tan elevada de muertes, de no desarrollarse nuevos fármacos en el futuro, el paludismo podrá matar a más gente. Es la parasitosis que más mata en el mundo, aun cuando actualmente se cuenta con un tratamiento relativamente eficaz" External link

noticiasdelaciencia Saturday, August 11, 2018 8:25:00 AM CEST

Mamadou Sarr expliqué: "S’agissant de la filariose lymphatique, une maladie parasitaire provoquée principalement par la femelle de le moustique (anophèle), la campagne cible toutes les populations à l’exception des femmes enceintes, des enfants de moins de 5 ans et les personnes très malades" External link

APS Wednesday, May 2, 2018 10:58:00 AM CEST

Mamadou Sarr assuré: "sur un objectif en taux de couverture de 65%, la région a reçu une quantité en médicaments équivalente à la population ciblée, plus 10% de réserve" External link

APS Wednesday, May 2, 2018 10:58:00 AM CEST

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