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Thursday, March 28, 2024

11:59:00 PM Central European Standard Time

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Marc Veldhoen said: “You could see B cell responses. T cell responses. Interferon type 1 responses. You see textbook immunology happening in real time,” External link

statnews Thursday, March 28, 2024 at 10:25:00 AM Central European Standard Time

Marion Pepper said: “As a 50-year-old researcher, I’ve never had the ability to access samples where I could track the evolution of an immune response from what we call naive cells that have never been activated before to multiple boosts that were timed,” External link

statnews Thursday, March 28, 2024 at 10:25:00 AM Central European Standard Time

Steven Deeks said: “We knew something was going to happen. We had no idea what it was going to be. And we figured, well, let’s just start doing what we do best, which is collecting data, collecting samples, and observing people,” External link

statnews Thursday, March 28, 2024 at 10:25:00 AM Central European Standard Time

John Wherry said: “Do I lay in bed at night wishing we had done it at a 10- or a 100-fold larger scale? It pains me, because we can only ask a limited number of questions, because [a biobank is] a very expendable resource,” External link

statnews Thursday, March 28, 2024 at 10:25:00 AM Central European Standard Time

Steven Deeks said: “You couldn’t have designed a better experiment. All the other viruses basically disappeared,” External link

statnews Thursday, March 28, 2024 at 10:25:00 AM Central European Standard Time

Marion Pepper said: “For people who study the flu, this has been a frustration forever. Because you don’t know what the history of exposure or vaccination, or any of these things, really, has been,” External link

statnews Thursday, March 28, 2024 at 10:25:00 AM Central European Standard Time

Christian Andersen said: “So we are developing [immunity] de novo. The virus comes in and immunity goes from there. That’s the first opportunity where you can actually [study] that at a very large scale,” External link

statnews Thursday, March 28, 2024 at 10:25:00 AM Central European Standard Time

Marion Pepper said: “Our control samples taken prior to the pandemic and vaccination look VERY different for most parameters,” External link

statnews Thursday, March 28, 2024 at 10:25:00 AM Central European Standard Time

Christian Andersen said: “To me the main thing that really stands out is that I think we have gotten a much, much, much, much better understanding of the sort of tight connection between population immunity and viral evolution,” External link

statnews Thursday, March 28, 2024 at 10:25:00 AM Central European Standard Time

Marion Koopmans said: “I think the almost synchronized nature of some of these waves in a weird sense also provided an opportunity where you could actually disentangle the impact of different aspects of immunity on transmission,” External link

statnews Thursday, March 28, 2024 at 10:25:00 AM Central European Standard Time

Marion Pepper said: “I think we almost thought that as long as you had the same number of exposures — let’s say, you had three vaccines or two vaccines and then an infection — that maybe you would get the same end result. And that’s not what we saw,” “We saw that you actually ended up with different abilities of those cells. The cells could do different things. And that’s what we study now” External link

statnews Thursday, March 28, 2024 at 10:25:00 AM Central European Standard Time

John Wherry said: “The fact that a viral infection could provoke de novo antibodies against the molecules your immune system uses to communicate with itself … that’s devious,” External link

statnews Thursday, March 28, 2024 at 10:25:00 AM Central European Standard Time

Scott Hensley said: “It is possible that [future] variant vaccines might elicit a mostly non-neutralizing antibody response,” External link

statnews Thursday, March 28, 2024 at 10:25:00 AM Central European Standard Time

Alessandro Sette said: “One would like, for example, to know in the context of booster vaccinations: How does the immune response of someone that has been immunized two or three times compare to someone who has [been immunized] four or five times,” “And those studies are now difficult to perform exactly for the reason that it’s very difficult to find someone that was immunized only once” External link

statnews Thursday, March 28, 2024 at 10:25:00 AM Central European Standard Time

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